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Biological Research For Nursing, Vol. 1, No. 4, 287-298 (2000)
DOI: 10.1177/109980040000100405

Cytokines and the Anorexia of Infection: Potential Mechanisms and Treatments

Donna O. McCarthy, PhD, RN

University of Wisconsin-Madison School of Nursing.

Anorexia during infection is thought to be mediated by immunoregulatory cytokines such as interleukins 1 and 6 and tumor necrosis factor. This article reviews the potential mechanisms of action by which these cytokines are thought to suppress food intake during infection and examines the proposition that blocking of cytokine activity might be one approach to improving food intake of the infected host.

Key Words: Animal models • interleukin-1alpha • interleukin-1beta • interleukin-6 • tumor necrosis • factor alpha • anorexia • infection • lipopolysaccharide


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