This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Knobf, M. T. Articles by Thompson, A. S. Search for Related Content PubMed Articles by Knobf, M. T. Articles by Thompson, A. S. Social Bookmarking                         What's this?

An Aerobic Weight-Loaded Pilot Exercise Intervention for Breast Cancer Survivors: Bone Remodeling and Body Composition Outcomes

Yale University School of Nursing, tish.knobf{at}yale.edu

Karl Insogna, MD

Departments of Medicine

Loretta DiPietro, PhD

Yale University School of Nursing

Kristopher Fennie, PhD

Yale University School of Nursing

A. Siobhan Thompson, MPH

Yale University School of Nursing

Objective. Weight gain and bone loss are commonly reported in breast cancer survivors. The purpose of this pilot study is to assess feasibility and explore the effect of an aerobic weight-loaded exercise intervention on bone remodeling, weight, and body composition.

Design. A one-group pre-posttest design was used to test a 16—24-week supervised walking exercise intervention among women within 2 years of menopause. Through Weeks 1—4, time and weight were progressively increased. By Week 5 and through the end of the intervention, a waist belt was loaded with 5 lb and participants spent 45 min on the treadmill 3 times/week. Bone remodeling was measured by serum biomarkers (N-terminal propeptides of type I collagen [NTX] and serum osteocalcin). Dual-energy absorptiometry scans assessed body composition. Data were collected at baseline and 16 and 24 weeks.

Results. The majority of the 26 participants were married, well educated, and employed, with a mean age of 51.3 years (SD = 6.2). The high adherence (M = 88.2%, SD = 6.8) demonstrated feasiblity. There were no significant changes in serum osteocalcin (p = .67), serum NTX (p = .31), lean muscle mass (p = .08), or percent fat mass for the group as a whole (p = .14), but fat mass increased for women on adjuvant endocrine therapy (p = .04). The women maintained their weight.

Conclusions. This novel exercise intervention for breast cancer survivors was feasible, and women otherwise at high risk for weight gain and bone loss maintained their weight and bone mass.

Key Words: breast cancer • exercise • bone loss • body composition • cancer survivors

Biological Research For Nursing, Vol. 10, No. 1, 34-43 (2008)
DOI: 10.1177/1099800408320579


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?