This Article Full Text (PDF) All Versions of this Article: 1099800408323221v1 10/3/205    most recent References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Gallek, M. J. Articles by Alexander, S. A. Search for Related Content PubMed PubMed Citation Articles by Gallek, M. J. Articles by Alexander, S. A. Social Bookmarking                         What's this?

APOE Genotype and Functional Outcome Following Aneurysmal Subarachnoid Hemorrhage

School of Nursing University of Pittsburgh, Pittsburgh, Pennsylvania, mgallek{at}nursing.arizona.edu

Yvette P. Conley, PhD

School of Nursing University of Pittsburgh, Pittsburgh, Pennsylvania

Paula R. Sherwood, RN, PhD

School of Nursing University of Pittsburgh, Pittsburgh, Pennsylvania

Michael B. Horowitz, MD

Department of Neurosurgery University of Pittsburgh, Pittsburgh, Pennsylvania

Amin Kassam, MD

Department of Neurosurgery University of Pittsburgh, Pittsburgh, Pennsylvania

Sheila A. Alexander, RN, PhD

School of Nursing University of Pittsburgh, Pittsburgh, Pennsylvania

Apolipoprotein E (apoE), the major apolipoprotein in the central nervous system, has been shown to influence neurologic disease progression and response to neurologic injury in a gene-specific manner. Presence of the APOE4 allele is associated with poorer response to traumatic brain injury and ischemic stroke, but the association between APOE genotype and outcome following aneurysmal subarachnoid hemorrhage (SAH) remains unclear. The purpose of this project was to investigate the association between APOE genotype and outcome after SAH. We also explored the association of APOE4 genotype and cerebral vasospasm (CV) presence in a subsample of our population with available angiographic data. A sample of 206 aneurysmal SAH participants had APOE genotyping performed, Glasgow outcome scores (GOS) and modified Rankin scores (MRS) collected at 3 and 6 months after aneurysm rupture. No significant association was found between the presence of the APOE4 genotype and functional outcomes controlling for age, race, size of hemorrhage (Fisher grade), and severity of injury (Hunt & Hess grade). However when controlling for CV and the covariates listed above, individuals with the APOE4 allele had worse functional outcomes at both time points. The presence of the APOE2 allele was not associated with functional outcomes even when considering presence of CV. There was no difference in mortality associated with APOE4 presence, APOE2 presence, or presence of CV. These findings suggest APOE4 allele is associated with poor outcome after aneurysmal SAH.

Key Words: apolipoprotein E • subarachnoid hemorrhage • cerebral vasospasm • Modified Rankin Score • Glasgow Outcome Score

This version was published on January 1, 2009

Biological Research For Nursing, Vol. 10, No. 3, 205-212 (2009)
DOI: 10.1177/1099800408323221


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?