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Biological Research For Nursing
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Lateral Hypothalamic-Induced Alpha-Adrenoceptor Modulation Occurs in a Model of Inflammatory Pain in Rats

Younhee Jeong, PhD, RN

College of Nursing Science, Kyunghee University, Seoul, Korea

Janean E. Holden, PhD, RN

University of Illinois at Chicago, and Department of Medical-Surgical Nursing, College of Nursing, Chicago, Illinois, jeholden{at}uic.edu

Previous work from our lab showed that stimulation of the lateral hypothalamus (LH) produces analgesia (antinociception) in a model of thermal nociceptive pain. This antinociceptive effect is mediated by {alpha}2-adrenoceptors in the spinal cord dorsal horn. However, a concomitant, opposing hyperalgesic (pro-nociceptive) response also occurs, which is mediated by {alpha}1-adrenoceptors in the dorsal horn. Antinociception predominates but is attenuated by the pronociceptive response. To determine whether such an effect occurs in a model of inflammatory pain, we applied mustard oil (allyl isothiocyanate; 20 µl) to the left ankle of female Sprague-Dawley rats. We then stimulated the LH using carbamylcholine chloride (carbachol; 125 nmol). The foot withdrawal latencies were measured. Some rats received intrathecal {alpha}-adrenoceptor antagonists to determine whether the opposing {alpha}-adrenoceptor response was present. Mustard oil application produced hyperalgesia in the affected paw, while the LH stimulation increased the foot withdrawal latencies for the mustard oil paw as compared to the control group. Following carbachol microinjection in the LH, WB4101, an {alpha}1-adrenoceptor antagonist, produced significantly longer foot withdrawal latencies compared to saline controls, while yohimbine, an {alpha}2-antagonist, decreased the foot withdrawal latencies from 10 min postinjection (p < .05). These findings support the hypothesis that the LH-induced nociceptive modulation is mediated through an {alpha}-adrenoceptor opposing response in a model of inflammatory pain.

Key Words: antagonist • A7 cell group • norepinephrine

This version was published on April 1, 2009

Biological Research For Nursing, Vol. 10, No. 4, 331-339 (2009)
DOI: 10.1177/1099800408325053
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