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Association Between Stress-Related Substances in Saliva and Immune Substances in Breast Milk in Puerperae

Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1-D, Tennodai Tsukuba, Ibaraki, Japan, aatsuko313{at}hotmail.com

Yoko Emori, PhD

Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1-D, Tennodai Tsukuba, Ibaraki, Japan

Sachiyo Miyagawa

From the Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1-D, Tennodai Tsukuba, Ibaraki, Japan

Objective: We examined the association between biochemical parameters of stress in puerperae and immune substances in breast milk. Methods: The participants were 22 mothers 2 weeks after delivery, with normal pregnancy/delivery and a normal puerperal course. We measured the levels of secretory immunoglobulin A (SIgA) and cortisol in saliva and the level of SIgA and the leukocyte count in breast milk and investigated their association. Results: There was a positive correlation between the salivary and breast milk levels of SIgA (r = .536, p < .05). However, there were no correlations among the salivary level of cortisol and the level of SIgA and leukocyte count in breast milk. Conclusions: The only association found in our study was between the salivary and breast milk SIgA. The lack of association among SIgA and cortisol may be related to a variety of factors such as production site, diurnal rhythms, and the interval between stress stimulation in mothers and the response of the biomarker.

Key Words: stress biomarkers • puerperal period • salivary SIgA • salivary cortisol • breast milk SIgA • breast milk leukocytes

This version was published on April 1, 2009

Biological Research For Nursing, Vol. 10, No. 4, 350-355 (2009)
DOI: 10.1177/1099800409331892


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