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Biological Research For Nursing
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Reviews

The Interplay Between Secondhand Cigarette Smoke, Genetics, and Cervical Cancer: A Review of the Literature

Natalie Pate Capps, MNSc, RN

University of Arkansas for Medical Sciences, Little Rock, Arkansas, NJCapps{at}uams.edu

Ayasha Stewart, MNSc, APN

University of Arkansas for Medical Sciences, Little Rock, Arkansas

Cindy Burns, MSN, CNM

University of Arkansas for Medical Sciences, Little Rock, Arkansas

Research has suggested a link between smoking and cervical cancer; however, little data are available on secondhand smoke (SHS) exposure and cervical cancer risk. This article reviews the literature on the links among smoking, SHS exposure and cervical cancer. The review was based on a search of electronic databases. The research reviewed clearly showed that smoking increases cervical cancer risk through myriad mechanisms that interact with genetics and the pathologic processes leading to cervical cancer. However, less is understood about the role of SHS in cervical cancer. With new technology enabling scientists to examine how genomic structure responds to environmental stimuli, more information should be forthcoming on links between SHS exposure, biomarkers, and genetic changes involved in the development of cervical cancer.

Key Words: smoking • secondhand smoke • cervical cancer • genetics • carcinogenic load • mutability factors • human biomarkers • passive smoking

This version was published on April 1, 2009

Biological Research For Nursing, Vol. 10, No. 4, 392-399 (2009)
DOI: 10.1177/1099800408330849
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