Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Click here to sign up for SAGE Journal Email Alerts today!

Sign In to gain access to subscriptions and/or personal tools.
Biological Research For Nursing
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
1099800409333169v1
11/1/98    most recent
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Kaspar, R. W.
Right arrow Articles by Kaspar, B. K.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kaspar, R. W.
Right arrow Articles by Kaspar, B. K.
Right arrowPubmed/NCBI databases
Medline Plus Health Information
*Genes and Gene Therapy
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Gene Therapy and Informed Consent Decision Making: Nursing Research Directions

Rita W. Kaspar, BSN, RN

College of Nursing

Celia E. Wills, PhD, RN

College of Nursing, The Ohio State University, Columbus, Ohio, wills.120{at}osu.edu

Brian K. Kaspar, PhD

Center for Gene Therapy The Research Institute at Nationwide Children's Hospital, Columbus, Ohio, Department of Pediatrics, College of Medicine The Ohio State University, Columbus, Ohio

Recent gene therapy clinical trials have demonstrated significant promise for treating a number of genetic neuromuscular disorders. Although nurses are experienced in educating patients and families about the benefits and risks of conventional therapeutics, there are significant challenges for guiding patients through the decision-making phase of gene therapy clinical trial participation. The first part of this review provides an overview and update on neuromuscular gene therapy, including viral delivery principles and historical progress. The second part discusses risk/benefit perception of gene therapy and factors affecting the decision making for patients interested in participating in a trial. Future challenges for gene therapy are targeted high-efficiency delivery, and additional research on developing patient-centered decision support interventions.

Key Words: gene therapy • informed consent • decision making • neuromuscular disorders

This version was published on July 1, 2009

Biological Research For Nursing, Vol. 11, No. 1, 98-107 (2009)
DOI: 10.1177/1099800409333169
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?