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Biological Research For Nursing
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Tissue and Wound Healing Effects of Short Duration Postoperative Oxygen Therapy

JoAnne D. Whitney, RN, PhD

Box 357266, Department of Biobehavioral Nursing and Health Systems, University of Washington, Seattle, WA 98195; phone: (206) 685-2264; fax: (206) 543-4771joiewhit{at}u.washington.edu

Stacy Heiner, RN, BSN

Nursing Research Service, Madigan Army Medical Center, Tacoma, Washington.

Brenda I. Mygrant, LTC, AN

Surgical Intensive Care Unit, Brooke Army Medical Center, San Antonio, Texas.

Connie Wood, RN

Madigan Army Medical Center, Tacoma, Washington.

The purpose of this study was to determine the effects of 28% oxygen given in the first 36 hours after surgery on tissue oxygen, collagen deposition, and clinical healing outcomes. Twenty-four subjects having cervical spine surgical procedures participated in a randomized, repeated-measures pilot study of tissue and healing effects of postoperative supplemental oxygen. The treatment group (n = 13) received 28% oxygen for the first 36 postoperative hours, whereas the control group (n = 11) was maintained on room air. Subcutaneous tissue oxygen and temperature were measured at intervals up to 36 hours postsurgery. Wound healing was evaluated by hydroxyproline content in a subcutaneous polytetrafluoroethylene tube removed on the 7th postoperative day. Clinical outcomes were evaluated for the 30 days post–hospital discharge. Subjects in the treatment group had significantly higher tissue oxygen tension overall, and at postoperative hours 1, 2, 18, and 36, with mean values 10 to 20 mm Hg higher than control subjects. Significant differences were not found in hydroxyproline levels or clinical wound outcome measures. Low level, short duration, supplemental oxygen increased and sustained wound tissue oxygen and was well tolerated by subjects. Larger studies of populations at risk for wound complications are needed to investigate variables of dose and duration of oxygen therapy in relation to clinical and cellular wound healing outcomes.

Key Words: Wound healing • tissue oxygen • oxygen inhalation therapy • surgery

Biological Research For Nursing, Vol. 2, No. 3, 206-215 (2001)
DOI: 10.1177/109980040100200306
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Home page
 ThoraxHome page
B R O'Driscoll, L S Howard, A G Davison, and on behalf of the British Thoracic Society
BTS guideline for emergency oxygen use in adult patients
Thorax, October 1, 2008; 63(Suppl_6): vi1 - vi68.
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