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Biological Research For Nursing
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Predictors of Fatigue in Healthy Young Adults: Moderating Effects of Cigarette Smoking and Gender

Elizabeth J. Corwin, PhD, RN, CRNP

School of Nursing, The Pennsylvania State University, 307 Health and Human Development East, University Park, PA 16802ejc8{at}psu.edu

Laura Cousino Klein, PhD

Department of Biobehavioral Health at The Pennsylvania State University.

Kristin Rickelman, RN, MS, CRNP

Fatigue is a common complaint of patients seen in primary care. Factors that contribute to fatigue in a patient population include poor health status, psychological stress, poor nutrition, and pregnancy. Less well understood are factors that contribute to fatigue among healthy, nonpregnant individuals. Within the framework of the theory of unpleasant symptoms, 40 healthy young smoking and nonsmoking adults between the ages of 18 and 35 were evaluated to determine self-report level of fatigue and contributing physiological, psychological, and situational factors. Results indicate that while self-report of fatigue did not vary in this population based on gender, subjects who were moderate to heavy cigarette smokers were significantly more fatigued than were nonsmokers (F= 10.24, df = 1, 38, P < 0.01), with the effect being specific to male smokers. Self-report of fatigue did not correlate with body mass index, baseline inflammatory or immune status, or blood pressure. Positive psychological and situational predictors of fatigue included depression (r = 0.556, P < 0.001), state anxiety (r = 0.569, P < 0.001), sleep quality (r = –0.399, P < 0.05), and sleep quantity (r = –0.411, P < 0.05). These results suggest that psychological and situational factors are key contributors to fatigue in young adults and that smoking is a risk factor for fatigue in men.

Key Words: fatigue • depression • healthy people • smoking • cytokines • C-reactive protein • theory of unpleasant symptoms

Biological Research For Nursing, Vol. 3, No. 4, 222-233 (2002)
DOI: 10.1177/109980040200300407
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