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Biological Research For Nursing, Vol. 4, No. 2, 115-127 (2002)
DOI: 10.1177/1099800402238332

Major Histocompatibility Complex (MHC) Tetramer Technology: An Evaluation

Carolyn M. Constantin, RNC, MSN, PhC

Elizabeth E. Bonney, MD

John D. Altman, PhD

Ora L. Strickland, PhD, RN, FAAN

Single-cell assays are currently favored to quantitate T-cell responses. Staining antigen-specific T-cells with fluorescently labeled tetrameric major histocompatibility complex (MHC)/peptide complexes has greatly enhanced the ability to assess the cellular dynamics of an immune response at the single-cell level.This article reviews MHC tetramer technology, defining it, discussing how MHC tetramers are made, outlining the benefits of this technology, comparing and contrasting it to other methods for evaluating immune responses, and describing current applications.

Key Words: tetramer • CD8+ T-cell • MHC class I • immune function • assay • lymphocyte


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