This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Lennie, T. A. Search for Related Content PubMed PubMed Citation Articles by Lennie, T. A. Social Bookmarking                   What's this?

Sex Differences in Severity of Inflammation-Induced Anorexia and Weight Loss

College of Nursing at the University of Kentucky, Lexington, tlennie{at}uky.edu

Food intake and body weight changes in response to induction of acute inflammation were examined in intact cycling females, ovariectomized females, and sham-operated male rats. In intact females, body weight and feeding responses were compared between rats in which inflammation was induced on day of estrus with rats in which inflammation was induced on day of diestrus. Anorexia and weight loss were more severe in the female rats with inflammation induced on estrus day, which coincides with peak serum estrogen levels. In ovariectomized females, inflammation was induced the day after rats received injections of estrogen, progesterone, or sesame oil (vehicle). Males received vehicle injections. Among female rats, the group that received estradiol injections the previous day displayed the most severe anorexia. The least severe anorexia was observed in female rats that received progesterone the previous day. Food intake of female rats that received vehicle injections prior to induction of inflammation was greater than the rats receiving estrogen but less than the rats receiving progesterone. Male rats displayed the most severe anorexia and greatest weight loss. These data suggest that, although females exposed to estradiol prior to induction of acute inflammation display more severe anorexia than those exposed to progesterone, it may be that progesterone attenuates severity of anorexia rather than estrogen solely potentiating severity. Male rats, however, appear to experience the most severe anorexia in response to this form of inflammation.

Key Words: estrus cycle • estrogen • progesterone • inflammation • food intake • body weight

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				K. Santora, C. Rasa, D. Visco, B. G. Steinetz, and C. A. Bagnell Antiarthritic Effects of Relaxin, in Combination with Estrogen, in Rat Adjuvant-Induced Arthritis J. Pharmacol. Exp. Ther., August 1, 2007; 322(2): 887 - 893. [Abstract] [Full Text] [PDF]

				J. J. Carrero, A. R. Qureshi, J. Axelsson, C. M. Avesani, M. E Suliman, S. Kato, P. Barany, S. Snaedal-Jonsdottir, A. Alvestrand, O. Heimburger, et al. Comparison of nutritional and inflammatory markers in dialysis patients with reduced appetite Am. J. Clinical Nutrition, March 1, 2007; 85(3): 695 - 701. [Abstract] [Full Text] [PDF]