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Biological Research For Nursing
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Integrating Molecular Genetics Analyses Into Clinical Research

Debra L. Schutte, RN, PhD

University of Iowa College of Nursing, Iowa City, debra-schutte{at}uiowa.edu

Ann Marie McCarthy, RN, PhD, FAAN

University of Iowa College of Nursing, Iowa City

Milena Floria-Santos, PhD, RN

University of Iowa College of Nursing, Iowa City

Kirsten Hanrahan, MA, ARNP

University of Iowa College of Nursing, Iowa City

Jeffrey C. Murray, MD

University of Iowa College of Medicine, Iowa City

Charmaine Kleiber, RN, PhD, FAAN

University of Iowa College of Nursing, Iowa City

The integration of molecular genetics approaches into the study of complex health phenomena is an increasingly important and available strategy for researchers across the health science disciplines. Pain sensation and response to painful stimuli are examples of complex health phenomena that are particularly amenable to molecular genetics approaches. Both human and animal model research suggests that differences in these responses may be related, in part, to variation in the genes that modulate sensation and behavior. The authors are currently managing a large cross-disciplinary research effort to identify child characteristics, including genotypes, that predict the degree of distress displayed by children following a painful medical procedure (i.e., IV insertion). The purpose of this article is to describe the strategies used to integrate molecular genetics methods into this project. The authors discuss the steps needed to complete this process, including (a) establishing a collaboration with genetics researchers and laboratory facilities, (b) developing and implementing a plan to manage biologic samples, and (c) incorporating genetics into the informed consent process.

Key Words: child • genetics • pain • research methodology

Biological Research For Nursing, Vol. 8, No. 1, 67-77 (2006)
DOI: 10.1177/1099800406289909
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