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Antinociceptive Effects of the Aqueous Extract of Brugmansia suaveolens Flowers in Mice

Programa de Pós-Graduação em Enfermagem, Fundação Universidade Federal do Rio Grande, Rio Grande, Brazil

Gianni Goulart Peraza, MSc

Programa de Pós-Graduação em Ciências Fisiológicas - Fisiologia Animal Comparada, Fundação Universidade Federal do Rio Grande, Rio Grande, Brazil

Janaina Sena, MSc

Fundação Universidade Federal do Rio Grande, Rio Grande, Brazil

Eli Sinnott Silva, MSc

Departamento de Ciências Fisiológicas, Fundação Universidade Federal do Rio Grande, Rio Grande, Brazil

Maria Cristina Flores Soares, PhD

Departamento de Ciências Fisiológicas and in the Programa de Pós-Graduação em Enfermagem, Fundação Universidade Federal do Rio Grande, Rio Grande, Brazil

Marta Regina Cezar Vaz, PhD

Departamento de Enfermagem and in the Programa de Pós-Graduação em Enfermagem, Fundação Universidade Federal do Rio Grande, Rio Grande, Brazil

Eliana Badiale Furlong, PhD

Departamento de Química and the Programa de Pós-Graduação em Engenharia de Alimentos, Fundação Universidade Federal do Rio Grande, Rio Grande, Brazil

Ana Luiza Muccillo-Baisch, PhD

Departamento de Ciências Fisiológicas, Programa de Pós-Graduação em Ciências Fisiológicas - Fisiologia Animal Comparada, and the Programa de Pós-Graduação em Enfermagem, Fundação Universidade Federal do Rio Grande, Rio Grande, Brazil, abaisch{at}octopus.furg.br

The infusion of Brugmansia suaveolens, popularly known as trombeteira or cartucheira, has been used to treat pain in Brazil. The present study was conducted to test for its antinociceptive effects using the abdominal-writhing, formalin, tail-flick, and hot-plate tests in mice. The aqueous extract from B. suaveolens flowers administered intraperitoneally at doses of 100 and 300 mg/kg body weight significantly inhibited acetic acid-induced abdominal constrictions. An increase in hot-plate latency was also observed in animals receiving both doses (100 and 300 mg/kg). In the formalin test, both doses from the aqueous extract inhibited the first (0-5 min) and second phase (20-25 min). Tail-flick assays demonstrated that treatment of animals with plant extract induced attenuation of the response. These results suggest that the aqueous extract from B. suaveolens flowers produced antinociceptive effects, as demonstrated in the experimental models of nociception in mice. This supports popular medicinal uses of this plant as an analgesic.

Key Words: Brugmansia suaveolens • antinociceptive effect • nurse scientists • basic science • abdominal constriction • hot-plate • formalin test • tail flick

Biological Research For Nursing, Vol. 8, No. 3, 234-239 (2007)
DOI: 10.1177/1099800406293984


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