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Biological Research For Nursing, Vol. 9, No. 3, 231-243 (2008)
DOI: 10.1177/1099800407311016
© 2008 SAGE Publications

Sleep Disorders, Glucose Regulation, and Type 2 Diabetes

Leslie-Faith Morritt Taub, DNSc, ANP-C, GNP-BC, CDE

University of Medicine and Dentistry of New Jersey School of Nursing, Newark, New Jersey , taublm{at}umdnj.edu

Nancy S. Redeker, PhD, RN

Yale University School of Nursing, New Haven, Connecticut

Recent epidemiological, biological, and behavioral evidence suggests that sleep disorders may contribute to the development of diabetes; conversely, diabetes itself may contribute to sleep disorders. Sleep appears to moderate the neurohormones that regulate blood glucose. Sleep deprivation and sleep disorders contribute to pathophysiological changes associated with the development of type 2 diabetes. In people who already have diabetes, sleep deprivation contributes to elevations of hemoglobin A1c. Symptoms that occur as a result of diabetes, such as nocturia and neuropathic pain, may in turn contribute to sleep disturbance and exacerbate sleep deprivation. The purposes of this article are to examine the scientific basis for the associations between diabetes and sleep, identify gaps in the understanding of the empirical underpinnings of these relationships, and propose directions for future research.

Key Words: diabetes • sleep • sleep apnea • insulin resistance • circadian rhythm • inflammatory markers


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