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Biological Research For Nursing
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A Randomized Clinical Trial of Elk Velvet Antler in Rheumatoid Arthritis

Marion Allen, PhD, RN

University of Alberta, Edmonton, Alberta, Canada, marion.allen{at}ualberta.ca

Kathleen Oberle, PhD, RN

University of Calgary

Michael Grace, PhD

University of Alberta, Edmonton, Alberta, Canada

Anthony Russell, MD

University of Alberta, Edmonton, Alberta, Canada

Adeniyi J. Adewale, PhD

University of Alberta, Edmonton, Alberta, Canada

This article examines the effects of elk velvet antler on joint pain and swelling, patient/physician global assessment of disease activity, functional ability, quality of life, blood levels of C-reactive protein, and adverse events in persons with stage 2 to 3 rheumatoid arthritis experiencing residual symptoms after standard treatment. Patients (N=168) were enrolled in a 6-month randomized, triple-blind, placebo-controlled clinical trial. Instruments included the Arthritis Impact Measurement Scale, the Health Assessment Questionnaire, tender and swollen joint counts, and 100 mm-length visual analogue scales, along with blood tests. There were no significant differences between groups on any measures. The pattern of change of the measures across time points was essentially the same for both groups. Although some patients reported clinical improvements in their symptoms, there were no statistically significant differences between groups. Overall, elk velvet antler does not effectively manage residual symptoms in patients with rheumatoid arthritis.

Key Words: rheumatoid arthritis • elk velvet antler • efficacy • clinical trial

Biological Research For Nursing, Vol. 9, No. 3, 254-261 (2008)
DOI: 10.1177/1099800407309505
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