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Biological Research For Nursing, Vol. 9, No. 4, 280-292 (2008)
DOI: 10.1177/1099800407313385

Candidate Genes of the 5-Lipoxygenase Pathway in Acute Coronary Syndrome: A Pilot Study

Shu-Fen Wung, PhD, MS, RN, ACNP, FAAN

College of Nursing, University of Arizona, Tucson, Arizona, shufen{at}nursing.arizona.edu

Bradley E. Aouizerat, PhD

Department of Physiological Nursing, School of Nursing, University of California, San Francisco, California

Purpose. The purpose of this pilot study was to examine arachidonate 5-lipoxygenase (ALOX5) and ALOX5-activating protein (ALOX5AP) gene variations in patients with and without acute coronary syndrome (ACS). Methodology. Four and six single nucleotide polymorphisms spanning the ALOX5 and ALOX5AP genes, respectively, were genotyped in 19 non-Hispanic Caucasian patients with ACS and 27 controls. Results. Presence of the common allele of rs9508835 (ALOX5AP) and the minor allele of rs2029253 (ALOX5) were associated with ACS. After adjustment for age, being a carrier of the rs9508835 common allele was associated with an increased risk of ACS (odds ratio = 2.86). Relevance for nursing practice. Through the inhibition of the ALOX5AP gene by downregulation of the leukotriene pathway, the risk of ACS may be decreased in individuals that carry susceptibility allele(s). Knowledge of the genetic basis of treatments that downregulate the leukotriene pathway may prove essential to the care of individuals with ACS.

Key Words: acute coronary syndrome • myocardial infarction • single nucleotide polymorphism • haplotype • 5-lipoxygenase • genetics


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