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Effect of Early Low-Intensity Exercise on Rat Hind-Limb Muscles Following Acute Ischemic Stroke

College of Nursing, Seoul National University, Seoul, Korea, machoe{at}snu.ac.kr

Gyeong Ju An, PhD, RN

Department of Nursing, Catholic University of Daegu, Korea

Yoon-Kyong Lee, MSN, RN

College of Nursing, Seoul National University, Seoul, Korea

Ji Hye Im, MSN, RN

College of Nursing, Seoul National University, Seoul, Korea

Smi Choi-Kwon, PhD, RN

College of Nursing, Seoul National University, Seoul, Korea

Margaret Heitkemper, PhD, RN

Department of Biobehavioral Nursing and Health Systems, University of Washington, Seattle

This study examined the effects of daily low-intensity exercise following acute stroke on mass, Type I and II fiber cross-sectional area, and myofibrillar protein content of hind-limb muscles in a rat model. Adult male Sprague-Dawley rats were randomly assigned to 1 of 4 groups (n = 7-9 per group): stroke (occlusion of the right middle cerebral artery [RMCA]), control (sham RMCA procedure), exercise, and stroke-exercise. Beginning 48 hours post-stroke induction/sham operation, rats in the exercise group had 6 sessions of exercise in which they ran on a treadmill at grade 10 for 20 min/day at 10 m/min. At 8 days poststroke, all rats were anesthetized and soleus, plantaris, and gastrocnemius muscles were dissected from both the affected and unaffected sides. After 6 sessions of exercise following acute ischemic stroke, the stroke-exercise group showed the following significant (p < .05) increases compared to the stroke-only group: body weight and dietary intake, muscle weight of affected soleus and both affected and unaffected gastrocnemius muscle, Type I fiber cross-sectional area of affected soleus and both affected and unaffected gastrocnemius muscle, Type II fiber cross-sectional area of the unaffected soleus, both affected and unaffected plantaris and gastrocnemius muscle, Type II fiber distribution of affected gastrocnemius muscle, and myofibrillar protein content of both affected and unaffected soleus muscle. Daily low-intensity exercise following acute stroke attenuates hind-limb muscle atrophy in both affected and unaffected sides. The effects of exercise are more pronounced in the soleus and gastrocnemius as compared to the plantaris muscle.

Key Words: acute stroke • exercise • muscle weight • Type I and II fiber cross-sectional area • myofibrillar protein content • hind-limb muscle • rat

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Biological Research For Nursing, Vol. 7, No. 3, 163-174 (2006)
DOI: 10.1177/1099800405283566


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This Article Abstract Free Full Text (Free PDF) Free Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Choe, M.-A. Articles by Heitkemper, M. Search for Related Content PubMed PubMed Citation Articles by Choe, M.-A. Articles by Heitkemper, M. Pubmed/NCBI databases Medline Plus Health Information Stroke Social Bookmarking                         What's this?