Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

CiteULike is a free service for managing and discovering scholarly references - click here to get started.

Sign In to gain access to subscriptions and/or personal tools.
Biological Research For Nursing
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
1099800408324127v1
10/3/284    most recent
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Anderson, C. M.
Right arrow Articles by Johnson, L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Anderson, C. M.
Right arrow Articles by Johnson, L.
Right arrowPubmed/NCBI databases
*Substance via MeSH
Medline Plus Health Information
*High Risk Pregnancy
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Placental Insufficiency: Programming of Leptin Secretion, Blood Pressure, and Postnatal Growth in Two Generations of Sprague-Dawley Rats

Cindy M. Anderson, PhD, WHNP-BC

University of North Dakota, Grand Forks, North Dakota, cindyanderson{at}mail.und.edu

Faye Lopez, MPH

University of North Dakota, Grand Forks, North Dakota

Ashley Sandeen, BS

University of North Dakota, Grand Forks, North Dakota

LuAnn Johnson, MS

University of North Dakota, Grand Forks, North Dakota

Regulatory process may be altered in response to the intrauterine environment, leading to the development of altered growth trajectory and disease later in life. Previously, our lab reported reduced leptin levels in pregnant hypertensive Sprague-Dawley rat dams with placental insufficiency. The purposes of this study were to investigate the relationship between leptin levels, growth and hypertension in two generations of offspring exposed to placental insufficiency. Leptin levels were significantly different only at 12 weeks in female first generation offspring (p < 0.05). Variations in postnatal body and organ weights were evident in first generation females at 3 and 12 weeks of age. There were no significant correlations with plasma leptin levels and systolic blood pressure in offspring groups at any age point. Our findings indicate that fetal exposure to maternal hypertension and hypoleptinemia is associated with altered leptin and growth patterns in mature female offspring and not perpetuated to a second generation.

Key Words: leptin • postnatal growth • preeclampsia • hypertension • fetal programming

This version was published on January 1, 2009

Biological Research For Nursing, Vol. 10, No. 3, 284-291 (2009)
DOI: 10.1177/1099800408324127
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?